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Fifty-four male ICR mice (18–22 g) were purchased from the Experimental Animal Center of Yangzhou University (Yangzhou, China) and housed under controlled environmental conditions (23–27 °C and 12 h light/dark cycle) with free access to standard diet and water

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133 One observational study reported that 92% of patients experienced clinically significant improvement (25 mg daily titrated up to 75 mg daily over several weeks)