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GLP-1 agonist shortage responses Shortages of approved weight loss peptides like semaglutide triggered regulatory responses

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Reviews of triple-agonism therapeutics stress that the added glucagon axis introduces distinct considerations, including dose-related, mostly mild-to-moderate gastrointestinal adverse events common to all incretin agents, plus glucagon-specific effects on heart rate and glucose flux that require longer-term follow-up (Triple Agonism review 2025)