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Despite advancements in treatment—including chemotherapy, targeted therapy with epidermal growth factor receptor antibodies, and immunotherapy with immune checkpoint inhibitors—many CRC cases exhibit intrinsic or acquired resistance to cancer treatment, leading to limited treatment efficacy and high recurrence rates
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Pharmacokinetic parameters for NSI-189 in plasma were calculated using non-compartmental analysis using individual patient concentrations vs time graphs using SAS for Windows (Version 9.3, SAS Institute, Cary, NC, USA)
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