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By inhibiting NF-κB and activating Nrf2, these agents shift the cellular response from a pro-inflammatory to an antioxidative and cytoprotective state
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To assess whether GGCT metabolic enzymatic activity regulates changes in the TCA cycle, we predicted the structure of GGCT and constructed a mutant (E98A) in PC3 and DU145 cell lines [20] (Fig
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