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The statistical analysis of the hydrophilic fraction (Fig 2A and A′) yielded a regression model with high-quality parameters (R 2 = 0.99 [goodness of fit] and Q 2 = 0.94 [power in goodness of prediction] (23), CV-ANOVA test, P = 0.0006), and a clear class discrimination (Fig 2A)

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Each batch undergoes HPLC purity testing, dissolution testing for enteric coating performance, and content uniformity verification