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Knockdown of UCP genes could contribute to determine their role in mitigating ROS production and preventing oxidative stress at high temperatures, and could be focused on the insect tissues where these mitochondrial proteins cover particular importance, such as muscle or the fat body (Sanchez-Blanco et al., 2006) (Table 3)

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Omaveloxolone activates the Nrf2 pathway by blocking the ubiquitination and degradation of Nrf2 [9]