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[DOI] [PMC free article] [PubMed] [Google Scholar] 172.Piavchenko G, Alekseev A, Stelmashchuk O, Seryogina E, Zherebtsov E, Kuznetsova E, Dunaev A, Volkov Y, Kuznetsov S

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Second, SAMe exerts a regulatory function over CBS, since SAMe allosterically activates this enzyme controlling the flux towards transsulfuration pathway while reducing the remethylation of Hcy to methionine by inhibiting methylenetetrahydrofolate reductase (MTHFR) enzyme, depending on cellular excess or depletion of SAMe [13,49,50,51]