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It is worth noting that dysregulation of DNA methylation patterns has been linked to various brain disorders, including depression, anxiety, and cognitive decline (reviewed in: 14,15 )

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Why 68% of initial requests get denied (and what denials actually say) The 68% initial denial rate comes from a 2025 analysis of 8,400 Zepbound PA requests submitted to Express Scripts between June 2024 and March 2025 (Patel et al., Journal of Managed Care & Specialty Pharmacy , 2025)

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