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Opposite to the effects of GRK inhibition, a PKC inhibitor blunted short-term analgesic tolerance to morphine but not DAMGO (Hull et al., 2010), and in locus coeruleus neurones, cellular tolerance to DAMGO was not reversed by PKC inhibitors (Bailey et al., 2009a)
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In RA, arginine shifts energy metabolism from glycolysis to OXPHOS, thereby leading to metabolic reprogramming of osteoclasts and a bias toward M2 polarization, ultimately suppressing arthritis, blocking osteoclast formation, and preventing inflammatory bone loss and erosion (88)
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