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Clinical remission rates at week 12 were 15.9% (p = 0.066), 22.6% (p = 0.004) and 11.5% (p = 0.142) in the 50-, 200- and 600-mg groups, respectively, compared to 4.8% in the placebo arm.50 The primary endpoint of clinical remission at week 12 in the 600 mg dose group compared to placebo was not met at 6.7% (–2.9 to 16.3, P = 0.142).50 Nonetheless, the greater clinical response seen in the mirikizumab group supported proceeding to a phase III trial (LUCENT 1 and 2)

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