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In addition, the progressive worsening of insulin resistance with the progression of AD correlates with increased OS levels, DNA damage, and protein oxidation demonstrated by accumulation of protein-bound HNE, PC, and 3-nitrotyrosine (3-NT) (133, 403)

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For example, it is known that α-tocopherol can enter the brain, but it is unclear how far its supplementation elevates human brain levels (Halliwell, 2024)