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Importantly, efficient synaptic glutamate uptake, which is mainly transported by glutamate transporters of brain excitatory amino acid transporter 1 (EAAT1) and EAAT2 in astrocytes, is vital to avoid excitatory overstimulation and concurrent excitotoxic damage (Storck et al., 1992

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thaliana vtc mutants have been invaluable in elucidating ascorbate biosynthesis and, except for VTC3, their roles are now well established