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On the other hand, disruption of ZC3H7A , MCM8 or MCM9 were identified to drive GSC sensitivity to TMZ following a negative selection CRISPR KO screen in response to sublethal doses of TMZ [64]

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They included acyl-CoA synthetase, a protein with a Rieske (2Fe-2S) iron-sulfur cluster, enoyl-CoA hydratase, and ATP-binding cassette (ABC) transporter proteins