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40 SNEC, characterized by the loss of membrane integrity, release large amounts of modified intracellular and intranuclear macromolecules as well as ions into the surrounding interstitium
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Conversely, icFSP1, a potent AIFM2 inhibitor, selectively induces ferroptosis via phase separation in GPX4 knockdown Pfa1 and HT-1080 cells overexpressing AIFM2 [110]
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