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Similar content being viewed by others Subjects Introduction The year 2025 marks two major anniversaries that forever changed the fields of metabolism and cell signaling: the 50th anniversary of the discovery of rapamycin in 1975 1,2 and the 60th anniversary of the Medical Expedition to Easter Island (METEI) in 1964–1965, 3 during which soil samples, containing Streptomyces hygroscopicus , the bacterium that produces rapamycin, were collected

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doi: 10.3389/fphar.2020.00240 140 RandeniNBordigaMXuB