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Chitinase 1 (CHIT1), secreted by activated macrophages, could curb inflammatory responses, promote lipid uptake and cholesterol efflux in macrophages, and polarize macrophages towards an M2 phenotype, thus exerting protective effects against atherosclerosis [96]

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But newer research revealed that GIP receptor activation in the brain actually reduces appetite, and when combined with GLP-1 receptor activation, the metabolic benefits multiply

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