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Inhibitors of polyamine metabolism, such as alpha-difluoromethylornithine, lead to a reduction in polyamine production, and a disruption of the cell cycle and DNA synthesis in cancer cells [60,61]
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Despite the fact it is rarely found in tumors, however, MRP2 in normal cells may impact drug sensitivity because it can influence the distribution and elimination (and hence pharmacokinetics) of some anticancer drugs and their metabolites (see Fig
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