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Transcription factors such as Twist , Snail , and ZEB2 , which are directly regulated by hypoxia, play major roles in this process and share a frequent promoter: the HRE
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The structure of the dipeptide Val-Tyr complex, which was obtained by co-crystallisation of DAP BII (WT) with angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe), (dipeptide complex II, Table S1) is consistent with the above catalytic mechanism and provides insight into the sequential digestion mechanism of peptide substrates by DAP BII
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