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Citalopram prevents the reuptake of 5-hydroxytryptamine (5-HT) by inhibiting 5-HT transporter, blocking reuptake on the presynaptic membrane (Tiritilli (2000) found that oxygen deficit and glucose deprivation inhibit the contractive response of umbilical arteries to 5-HT, which implies that aerobic glycolysis can increase sensitivity to 5-HT

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Early on, Tsien recognized the critical role of calcium in developmental biology, identifying rapid increase of intracellular calcium levels in Xenopus laevis embryos upon T cell activation and during the cell cycle