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*Correspondence: Stanley Chung [email protected] This article was submitted to Clinical and Translational Physiology, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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These agents act as toxicants after intracellular accumulation of the parent compound or after renal or extrarenal hiptransformation