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About 10% of tirzepatide participants had a heart-rate increase above 20 bpm during escalation, compared with 3% on placebo.¹¹ A lean Japanese cohort reached +10 to +13 bpm, and 23% of Japanese participants at 15 mg crossed the abnormal-pulse threshold versus 7% of other participants, despite only 17% higher exposure.¹¹ Lean and East Asian bodies showed greater cardiovascular sensitivity than exposure alone predicted
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Standard treatments for fibromyalgia focus on symptom management through antidepressants, anticonvulsants, and pain medications, approaches that help some patients moderately but leave many struggling with inadequate relief and significant side effects
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