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The term "macrophage activation" (also referred to as "classical activation") was introduced by Mackaness in the 1960 s into the infection background to elucidate the antigen-dependent but non-specifically enhanced microbicidal activity of macrophages against BCG (bacillus Calmette-Guerin) and listeria following secondary exposure to pathogens (Mackaness (1962) j.exp.med.116: 381-406)
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