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Together, they are used in wellness settings to support muscle gain, fat loss, sleep quality, and recovery, though most uses here are off‑label

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For instance, the bacterial metabolite Pseudomonas quinolone signal (PQS) activates host histidine methyltransferase carnosine-N-methyltransferase (CNMT), leading to epigenetic upregulation of transferrin receptor 1 (TFR1) and enhanced iron uptake, thereby promoting ferroptosis (Jia et al., 2025)