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By contrast, renal-selective GRK4 knockdown normalizes the increased ETBR and AdipoR1 phosphorylation, and partially or fully restores the ETBR- and AdipoR1-mediated increase in sodium excretion and reduction of blood pressure in SHRs [21, 82]

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Agilent Mass Hunter Workstation Software-Data Acquisition for 6550A Series Q-TOF, version B.05.01 (B5125.3), was used for data processing and analysis