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A common cause of low vitamin B12 levels (but not necessarily of symptomatic deficiency) is the condition known as “food-cobalamin malabsorption,” in which vitamin B12 in food is absorbed poorly, but the crystalline vitamin B12 in vitamin pills is well absorbed (67

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Tumor necrosis factor-alpha (TNF-α) is crucial in promoting inflammation, inducing disc cell apoptosis, and stimulating catabolic enzyme expression, all of which accelerate IVDD progression [23]