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71 Pharmacologic or genetic intestinal epithelial MLCK inhibition prevented these TNF-induced increases in MLC phosphorylation, luminal fluid accumulation, and albumin (ie, leak pathway) permeability

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While retatrutide shows lower potency at human GLP-1 and glucagon receptors compared to natural ligands, it demonstrates higher potency at the GIP receptor by a factor of nearly 9x, and the combined effect is what drives the superior outcomes