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Staying well hydrated and starting with a lower dose can help minimize this effect

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For instance, a randomized, controlled pilot trial with older adults who had mild cognitive impairment found that eating one Brazil nut per day for six months increased blood selenium, boosted an antioxidant enzyme in red blood cells (glutathione peroxidase), and led to improvements in verbal fluency and constructional praxis (skills involving visual/spatial organization) compared to a control group