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The formation of a disulfide bond upon cyclization of DTT acts as a mimic of the disulfide formation in the oxidation of GSH to produce GSSG

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EphA4-induced spine loss was inhibited by block of cyclin-dependent kinase 5 (Cdk5) activity and, furthermore, involved the Cdk5-dependent activation of ephexin1 (Fu and others 2007), a guanine nucleotide exchange factor (GEF) that specifically activates the small GTPase RhoA and thus regulates reorganization of the actin cytoskeleton (Fig