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Sigmoidal dose-response curves and reliable estimates of IC50 values based on non-linear least-squares fitting to the available data could not be obtained since no significant inhibition of DNMT1 and PRMT3 was observed at the tested NNMT inhibitor concentrations (Table 6)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 14.Gar C., Rottenkolber M., Prehn C., Adamski J., Seissler J., Lechner A