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In autoimmune and inflammatory conditions such as systemic SLE, psoriasis, rheumatoid arthritis, and multiple sclerosis, metformin has been shown to reduce disease activity by decreasing pro-inflammatory cytokine production and altering T-cell metabolism (Sung et al., 2020

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plantarum S9 in MetS rodents resulted in an improvement in body weight, inflammation, insulin sensitivity, lipid profile, and accumulation of fat in the liver