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Specialised organelles called melanosomes are a prerequisite for melanin synthesis [184]

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The LC-MS/MS assay proved linear from 4.1–484 pmol/L (39.1–4560 ng/L), and the limits of detection and quantification were 1.5–4.1 pmol/L (14.5 ng/L and 39.1 ng/L), respectively, using highly sensitive triple quadrupole instruments