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The first FDA-approved intranasal powder for systemic action, Onzetra Xsail (sumatriptan), was introduced in 2016 for migraine treatment, followed by Baqsimi (glucagon) in 2019, marking a significant shift toward systemic drug delivery via the intranasal route (Shrewsbury, 2023)
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[DOI] [Google Scholar] 102.Stambolija V., Stambolija T.P., Holjevac J.K., Murselovic T., Radonic J., Duzel V., Duplancic B., Uzun S., Zivanovic-Posilovic G., Kolenc D., et al
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