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Several lines of evidence point to upregulation of vascular endothelial growth factor receptor 2 (VEGFR2) signaling and modulation of the nitric oxide system [Huang et al., Vascular Pharmacology, 2015]
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The condition encompasses a spectrum of pathophysiologic processes ranging from absolute insulin deficiency (Type 1) to progressive insulin secretory failure superimposed on insulin resistance (Type 2)
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