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A DHAR activity has long been known for GRX (Wells et al., 1990) and appears to be specific to this type, but its physiological importance remains unclear

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Although they are inhibited by GPX4 inhibitors such as RSL3 in vitro , treatment of cells with more specific TrxR inhibitors, e.g., TRi, does not induce ferroptosis [102] indicating that TrxR is not directly involved in ferroptosis