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In vivo animal experiments showed that daily administration of NNMTi for 28 days to diet‑induced obese (DIO) mice significantly upregulated the expression of lipolysis‑related genes (such as ATGL and HSL) and downregulated lipogenesis‑related genes (such as FAS and ACC), indicating that NNMTi effectively promotes fat breakdown and inhibits fat synthesis
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More studies that will elucidate the best ways for interfering with adipocyte formation, and give precise data on the safety and metabolism of potential anti-obesity treatment, will make adipogenesis molecular mechanisms powerful targets in fighting obesity
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