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Secondary antioxidant enzymes (glutathione reductase, glucose-6-phosphate dehydrogenase, glutathione-s-transferase, and ubiquinone) detoxify ROS and supply the NADPH and glutathione for primary antioxidant enzymes for proper functioning

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In this review we focused on the ontogenesis of the regulatory pathways involved in the disposition of APAP and on the variability between pediatric, adolescent, and adult patients