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About 50% of the histamine in the brain is from mast cells.[ref] Diphenhydramine (Benadryl) has the side effect of making people sleepy due to blocking the actions of histamine in the brain

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[Google Scholar] 159.Xu C, Sun L, Ren F, Huang P, Tian Z, Cui J, Zhang W, Wang S, Zhang K, He L, Zhang C, Hao Q, Zhang Y, Li M, Li W

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