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Fatigue Fatigue is a common symptom of B12 deficiency, but evidence that B12 beyond the correction of deficiency has any benefits for energy is lacking
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It drives the transition from proliferation to differentiation and increases the number and length of multinucleated myotubes in a dose‑dependent manner.The mechanism is mainly related to NNMT inhibition, restored NAD⁺ levels, and activation of the SIRT1‑PGC‑1α pathway
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