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↑ Schänzer, W

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Key distinctions between these two pathways include the need for molecular oxygen to aid in ring contraction and cobalt insertion: in the aerobic pathway, this occurs only after the synthesis of hydrogenobyrinic acid a , c ‐diamide (late stage), whereas in the anaerobic pathway (as shown in Figure 3), it occurs at the precorrin‐2 stage (early insertion)