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GSH is the most abundant non-protein thiol (concentration ranging from 0.1 mM to about 20 mM) in all three kingdoms of life: Bacteria (mostly Gram-negative, rarely Gram-positive), Archaea, and Eukarya, where it plays pleiotropic roles in cell life and resistance to stresses [3,5,11,15,18,20,21,87,88,89]