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Nanoparticle technology has shown great potential in converting poorly absorbed and physiologically unstable compounds into effective therapeutic agents (Han et al., 2024) (see Table 2)

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Constipation may be related to changes in the structure and shape of ICCs ( + cells inhibit smooth muscle activity by activating purinergic receptors ( There are close apposed between axons and mast cells in the gastrointestinal mucosa (Stead et al., 1989)