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B12 deficiency affects at least 6% of the UK population under 60, rising to between 10% and 20% in the over 60's

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The gut microbiota shapes a diverse pool of BAs, including FXR agonists (e.g., CDCA) and antagonists or modulators (e.g., taurine-β-muricholic acid (T-βMCA) in mice, glycoursodeoxycholic acid (GUDCA) in humans, isoDCA), adding regulatory complexity (88, 89)