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Adrenal fatigue presents differently for everyone but some of the most common symptoms associated with adrenal fatigue syndrome include: Bioidentical Hormones & Adrenal Fatigue Syndrome The leading cause of adrenal fatigue syndrome is the lack of hormone availability in the adrenal glands and, for this reason, replenishing hormones with bioidentical hormone replacement therapy can help women to nourish their adrenal glands and reduce the effects of adrenal fatigue syndrome