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🧪 Glutathione Depletion Pathways 1. Precursor Depletion - Key bottleneck: Cysteine availability. - Source: Diet or hepatic transsulfuration (methionine → homocysteine → cysteine). - Failure mode: Downregulation of cystathionine γ‑lyase (CSE) during
One of the key molecular sensors driving this adaptation is AMP-activated protein kinase (AMPK)
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H., Bernatowska E., Corbeel L., et al
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