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However, the immune evasion mechanisms of DTP cells often limit the therapeutic effect when CAR-T cell therapy is used alone (138, 139)

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In this context, the vitamin D–exercise axis should not be viewed as a replacement for these strategies, but rather as a complementary approach that may enhance metabolic resilience, musculoskeletal integrity, and neurovascular health, particularly in individuals with limited tolerance to aggressive weight-loss interventions

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