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The researchers propose that DSIP’s observed effects, particularly the selective increase in V3 and ADP/t without affecting VDNP, suggest that it does not stimulate the activity of respiratory chain enzymes or substrate transporters, as these would typically affect VDNP

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Animal models of depression show a decrease in cell proliferation (creation of new brain cells) as well as an increase in cell death (apoptosis).[ref] A relative lack of ATP due to mitochondrial dysfunction could also impact the ability of neurotransmitters to bind to their receptors