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In contrast, abundant evidence demonstrates that enhancing Nrf2 signaling is potently neuroprotective in models of neurodegeneration, although the exact mechanism by which this is achieved is unclear
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In prokaryotes, this intermediate is subsequently reduced with NADPH to hydroxybutyryl-CoA by acetoacetyl-CoA reductase, and hydroxybutyryl-CoA may then be polymerized to form PHB by the enzyme PHB synthase (Anderson and Dawes, 1990
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