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Moreover, the fact that knockdown of any single TCA-dependent NADPH-producing enzyme has such robust effects on the NADPH/NADP+ ratio (Figure S5B) suggests that these individual pathways are interconnected in a way that is not yet clear

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The cause of the vitamin B12 deficiency was not identified in this patient, and her intestinal update was normal.4 What is the mechanism in B12 that causes optic neuropathy