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Boini, University of Houston, United States Reviewed by Ferda Kaleagasioglu, University of Istinye, Türkiye Sumaya Akter, Noakhali Science and Technology University, Bangladesh Updates Copyright © 2025 Fan, Wei, Zhu, Yang, Tian, Wang, Du and Yang

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The strong correlation between entry of the receptor into the desensitised state and the extent of γ2L S327 phosphorylation, and in particular, the observation that the increased phosphorylation was completely blocked by expression of the non-desensitizing α1 V296L mutant, strongly suggests that entry of the receptors into the desensitized state is required for agonist-induced γ2L S327 phosphorylation