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First, some background: The name HRT is a little misleading—you’re not replacing any hormones but supplementing decreased estrogen, and in patients who still have a uterus, adding back progesterone or progestin, to minimize the risk of uterine cancer

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This can be viewed as a form of homeostatic plasticity, where the CAS enhances its activity to maintain a relatively constant level of neural firing in response to diminished peripheral sensory input